Mescaline

What is Mescaline

Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of lsd and psilocybin.buy Mescaline powder here,buy dmt,buy psychedelic drugs.

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It occurs naturally in the peyote cactus (Lophophora williamsii),the San Pedro cactus (Echinopsis pachanoi), the Peruvian torch (Echinopsis peruviana) and other members of the plant family Cactaceae. It is also found in small amounts in certain members of the bean family, Fabaceae, including Acacia berlandieri.However those claims concerning Acacia species have been challenged and have been unsupported in additional analysis.

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Mescaline is biosynthesized from tyrosine which, in turn, is derived from phenylalanine by the enzyme phenylalanine hydroxylase. In Lophophora williamsii (Peyote), dopamine converts into mescaline in a biosynthetic pathway involving mO-methylation and aromatic hydroxylation.

Tyrosine and phenylalanine serve as the metabolic precursors to synthesis of mescaline. Tyrosine can either undergo a decarboxylation via tyrosine decarboxylase to generate tyramine and subsequently undergo an oxidation at carbon 3 by a monophenol hydroxylase or first be hydroxylated by tyrosine hydroxylase to form L-DOPA and decarboxylated by DOPA decarboxylase. These create dopamine, which then experiences methylation by a catechol-O-methyltransferase (COMT) by an S-adenosyl methionine (SAM)-dependent mechanism. The resulting intermediate is then oxidized again by a hydroxylase enzyme, likely monophenol hydroxylase again, at carbon 5, and methylated by COMT. The product, methylated at the two meta positions with respect to the alkyl substituent, experiences a final methylation at the 4 carbon by a guaiacol-O-methyltransferase, which also operates by a SAM-dependent mechanism. This final methylation step results in the production of mescaline.

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